Anti-PLCG2 antibody [R42-7F-8] (STJA0035491)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human PLCG2
General Information
| Short Description | Rabbit monoclonal anti-PLCG2 for use in WB, IHC-P, IP and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP/FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R42-7F-8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200IP 1:50FC 1:50 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PLCG2 |
| Gene ID | 5336 |
| Uniprot ID | PLCG2_HUMAN |
| Immunogen | A synthesized peptide derived from human PLCG2 |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues by CSF1R. Phosphorylated on tyrosine residues by BTK and SYK.upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity. |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2Phosphoinositide Phospholipase C-Gamma-2Phospholipase C-IvPlc-IvPhospholipase C-Gamma-2Plc-Gamma-2 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-166016Reactome: R-HSA-1855204Reactome: R-HSA-202433Reactome: R-HSA-2029485Reactome: R-HSA-2424491Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-5607764Reactome: R-HSA-5621480Reactome: R-HSA-9027277Reactome: R-HSA-9664323Reactome: R-HSA-9679191Reactome: R-HSA-9680350Reactome: R-HSA-983695 |
| Cellular Localisation | Membrane Raft |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2 antibodyAnti-Phosphoinositide Phospholipase C-Gamma-2 antibodyAnti-Phospholipase C-Iv antibodyAnti-Plc-Iv antibodyAnti-Phospholipase C-Gamma-2 antibodyAnti-Plc-Gamma-2 antibodyAnti-PLCG2 antibody |
Information sourced from Uniprot.org