| Host: |
Rat |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
| Short Description : |
Rat monoclonal antibody anti-1-Phosphatidylinositol 4-5-Bisphosphate Phosphodiesterase Gamma-1 is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
SAA0275 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
0.01M PBS |
| Purification: |
Protein A/G purified from cell culture supernatant |
| Concentration: |
1 mg/mL |
| Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1Phosphoinositide Phospholipase C-Gamma-1Phospholipase C-Gamma-1Plc-Gamma-1 |
| Database Links | Reactome: R-MMU-1169408Reactome: -MMU-1855204Reactome: -MMU-186763Reactome: -MMU-201556Reactome: -MMU-202433Reactome: -MMU-2029485Reactome: -MMU-210990Reactome: -MMU-212718Reactome: -MMU-2424491Reactome: -MMU-2871796Reactome: -MMU-2871809Reactome: -MMU-5218921Reactome: -MMU-5654219Reactome: -MMU-5654221Reactome: -MMU-5654227Reactome: -MMU-5654228Reactome: -MMU-8853659Reactome: -MMU-9026527Reactome: -MMU-9034793 |
| Cellular Localisation | Cell ProjectionLamellipodiumRuffleRapidly Redistributed To Ruffles And Lamellipodia Structures In Response To Epidermal Growth Factor (Egf) Treatment |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1 antibodyAnti-Phosphoinositide Phospholipase C-Gamma-1 antibodyAnti-Phospholipase C-Gamma-1 antibodyAnti-Plc-Gamma-1 antibodyAnti-Plcg1 antibodyAnti-Plcg-1 antibody |
Information sourced from Uniprot.org
