| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Monoclonal |
| Clone ID: | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:4000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLCG1 |
| Gene ID: | 5335 |
| Uniprot ID: | PLCG1_HUMAN |
| Immunogen Region: | 710-832 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 710-832 of human PLC gamma 1 (PLC gamma 1 (PLCG1) ) (P19174). |
| Immunogen Sequence: | GKIKHCRVQQEGQTVMLGNS EFDSLVDLISYYEKHPLYRK MKLRYPINEEALEKIGTAEP DYGALYEGRNPGFYVEANPM PTFKCAVKALFDYKAQREDE LTFIKSAIIQNVEKQEGGWW RGD |
| Post Translational Modifications | Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA. Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells. Ubiquitinated by CBLB in activated T-cells. |
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1 Plc-148 Phosphoinositide Phospholipase C-Gamma-1 Phospholipase C-Ii Plc-Ii Phospholipase C-Gamma-1 Plc-Gamma-1 |
| Database Links | Reactome: R-HSA-1169408 Reactome: R-HSA-1236382 Reactome: R-HSA-1251932 Reactome: R-HSA-1489509 Reactome: R-HSA-167021 Reactome: R-HSA-1855204 Reactome: R-HSA-186763 Reactome: R-HSA-201556 Reactome: R-HSA-202433 Reactome: R-HSA-2029485 Reactome: R-HSA-210990 Reactome: R-HSA-212718 Reactome: R-HSA-2424491 Reactome: R-HSA-2871796 Reactome: R-HSA-2871809 Reactome: R-HSA-418890 Reactome: R-HSA-5218921 Reactome: R-HSA-5637810 Reactome: R-HSA-5654219 Reactome: R-HSA-5654221 Reactome: R-HSA-5654227 Reactome: R-HSA-5654228 Reactome: R-HSA-5655253 Reactome: R-HSA-5655291 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-8853659 Reactome: R-HSA-9026527 Reactome: R-HSA-9027277 Reactome: R-HSA-9034793 Reactome: R-HSA-9664323 Reactome: R-HSA-9664565 Reactome: R-HSA-9665348 Reactome: R-HSA-9665686 Reactome: R-HSA-9725370 |
| Cellular Localisation | Cell Projection Lamellipodium Ruffle Rapidly Redistributed To Ruffles And Lamellipodia Structures In Response To Epidermal Growth Factor (Egf) Treatment |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1 antibody Anti-Plc-148 antibody Anti-Phosphoinositide Phospholipase C-Gamma-1 antibody Anti-Phospholipase C-Ii antibody Anti-Plc-Ii antibody Anti-Phospholipase C-Gamma-1 antibody Anti-Plc-Gamma-1 antibody Anti-PLCG1 antibody Anti-PLC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
