Anti-PLCD4 antibody (1-290) (STJ110151)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PLCD4 (1-290) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLCD4 |
| Gene ID | 84812 |
| Uniprot ID | PLCD4_HUMAN |
| Immunogen Region | 1-290 |
| Immunogen Sequence | MASLLQDQLTTDQDLLLMQE GMPMRKVRSKSWKKLRYFRL QNDGMTVWHARQARGSAKPS FSISDVETIRNGHDSELLRS LAEELPLEQGFTIVFHGRRS NLDLMANSVEEAQIWMRGLQ LLVDLVTSMDHQERLDQWLS DWFQRGDKNQDGKMSFQEVQ RLLHLMNVEMDQEYAFSLFQ AADTSQSGTLEGEEFVQFYK ALTKRAEVQELFESFSADGQ KLTLLEFLDFLQEEQKERD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human PLCD4 (NP_116115.1). |
Additional Info
| Tissue Specificity | Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. |
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. Isoform 2: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Delta-4Hplcd4Phosphoinositide Phospholipase C-Delta-4Phospholipase C-Delta-4Plc-Delta-4 |
| Database Links | Reactome: R-HSA-1855204 |
| Cellular Localisation | MembranePeripheral Membrane ProteinNucleusCytoplasmEndoplasmic ReticulumLocalizes Primarily To Intracellular Membranes Mostly To The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Delta-4 antibodyAnti-Hplcd4 antibodyAnti-Phosphoinositide Phospholipase C-Delta-4 antibodyAnti-Phospholipase C-Delta-4 antibodyAnti-Plc-Delta-4 antibodyAnti-PLCD4 antibody |
Information sourced from Uniprot.org