| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-3 (501-551 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLCD3 |
| Gene ID: | 113026 |
| Uniprot ID: | PLCD3_HUMAN |
| Immunogen Region: | 501-551 aa |
| Specificity: | This antibody detects endogenous levels of PLCD3 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human PLCD3 at the amino acid range 501-551 |
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Delta-3Phosphoinositide Phospholipase C-Delta-3Phospholipase C-Delta-3Plc-Delta-3 |
| Database Links | Reactome: R-HSA-1855204 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmCleavage FurrowLocalizes At The Cleavage Furrow During Cytokinesis |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Delta-3 antibodyAnti-Phosphoinositide Phospholipase C-Delta-3 antibodyAnti-Phospholipase C-Delta-3 antibodyAnti-Plc-Delta-3 antibodyAnti-PLCD3 antibodyAnti-KIAA1964 antibody |
Information sourced from Uniprot.org