| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLCB3 |
| Gene ID: | 5331 |
| Uniprot ID: | PLCB3_HUMAN |
| Immunogen Region: | 1010-1234 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1010-1234 of human PLC beta 3 (PLCB3) (NP_001303243.1). |
| Immunogen Sequence: | GALGGAADVEDTKEGEDEAK RYQEFQNRQVQSLLELREAQ VDAEAQRRLEHLRQALQRLR EVVLDANTTQFKRLKEMNER EKKELQKILDRKRHNSISEA KMRDKHKKEAELTEINRRHI TESVNSIRRLEEAQKQRHDR LVAGQQQVLQQLAEEEPKLL AQLAQECQEQRARLPQEIRR SLLGEMPEGLGDGPLVACAS NGHAPGSSGHLSGADSESQE ENTQL |
| Function | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-3 Phosphoinositide Phospholipase C-Beta-3 Phospholipase C-Beta-3 Plc-Beta-3 |
| Database Links | Reactome: R-HSA-112043 Reactome: R-HSA-1855204 Reactome: R-HSA-399997 Reactome: R-HSA-4086398 Reactome: R-HSA-416476 Reactome: R-HSA-418217 Reactome: R-HSA-434316 Reactome: R-HSA-500657 |
| Cellular Localisation | Cytoplasm Membrane Nucleus And Particulate Fractions |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-3 antibody Anti-Phosphoinositide Phospholipase C-Beta-3 antibody Anti-Phospholipase C-Beta-3 antibody Anti-Plc-Beta-3 antibody Anti-PLCB3 antibody |
Information sourced from Uniprot.org