Anti-PLAU antibody (20-180) (STJ25021)

Name: Anti-PLAU antibody (20-180) (STJ25021)
SKU: STJ25021
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ25021

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Short Description	Rabbit polyclonal PLAU (20-180) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	PLAU
Gene ID	5328
Uniprot ID	UROK_HUMAN
Immunogen Region	20-180
Immunogen Sequence	GSNELHQVPSNCDCLNGGTC VSNKYFSNIHWCNCPKKFGG QHCEIDKSKTCYEGNGHFYR GKASTDTMGRPCLPWNSATV LQQTYHAHRSDALQLGLGKH NYCRNPDNRRRPWCYVQVGL KPLVQECMVHDCADGKKPSS PPEELKFQCGQKTLRPRFKI I
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 20-180 of human PLAU (NP_002649.1).

Tissue Specificity	Expressed in the prostate gland and prostate cancers.
Post Translational Modifications	Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4.
Function	Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Protein Name	Urokinase-Type Plasminogen Activator U-Plasminogen Activator Upa Cleaved Into - Urokinase-Type Plasminogen Activator Long Chain A - Urokinase-Type Plasminogen Activator Short Chain A - Urokinase-Type Plasminogen Activator Chain B
Database Links	Reactome: R-HSA-6798695 Reactome: R-HSA-75205
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Urokinase-Type Plasminogen Activator antibody Anti-U-Plasminogen Activator antibody Anti-Upa Cleaved Into - Urokinase-Type Plasminogen Activator Long Chain A - Urokinase-Type Plasminogen Activator Short Chain A - Urokinase-Type Plasminogen Activator Chain B antibody Anti-PLAU antibody

Information sourced from Uniprot.org