| Short Description : | Rabbit polyclonal PLA2G4D (510-680) antibody for use in IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLA2G4D |
| Gene ID: | 283748 |
| Uniprot ID: | PA24D_HUMAN |
| Immunogen Region: | 510-680 |
| Immunogen Sequence: | RLMRRIPEPRICFLEAIWSN IFSLNLLDAWYDLTSSGESW KQHIKDKTRSLEKEPLTTSG TSSRLEASWLQPGTALAQAF KGFLTGRPLHQRSPNFLQGL QLHQDYCSHKDFSTWADYQL DSMPSQLTPKEPRLCLVDAA YFINTSSPSMFRPGRRLDLI LSFDYSLSAPF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-680 of human PLA2G4D (NP_828848.3). |
| Tissue Specificity | Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin. |
| Function | Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. |
| Protein Name | Cytosolic Phospholipase A2 DeltaCpla2-DeltaPhospholipase A2 Group Ivd |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482801Reactome: R-HSA-1482839Reactome: R-HSA-1482922Reactome: R-HSA-1482925Reactome: R-HSA-1483115Reactome: R-HSA-1483166 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane ProteinCytoplasmic SideTranslocates To Perinuclear Membranes That May Correspond To Endoplasmic Reticulum Or Golgi In A Calcium-Dependent Fashion |
| Alternative Antibody Names | Anti-Cytosolic Phospholipase A2 Delta antibodyAnti-Cpla2-Delta antibodyAnti-Phospholipase A2 Group Ivd antibodyAnti-PLA2G4D antibody |
Information sourced from Uniprot.org
