| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLA2G2D (21-145) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:10-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLA2G2D |
| Gene ID: |
26279 |
| Uniprot ID: |
PA2GD_HUMAN |
| Immunogen Region: |
21-145 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 21-145 of human PLA2G2D (NP_036532.1). |
| Immunogen Sequence: |
GILNLNKMVKQVTGKMPILS YWPYGCHCGLGGRGQPKDAT DWCCQTHDCCYDHLKTQGCS IYKDYYRYNFSQGNIHCSDK GSWCEQQLCACDKEVAFCLK RNLDTYQKRLRFYWRPHCRG QTPGC |
| Tissue Specificity | Highly expressed in pancreas and spleen and less abundantly in colon, thymus, placenta, small intestine, and prostate. |
| Function | Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins. During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response. May act in an autocrine and paracrine manner. Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance. May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. |
| Protein Name | Group Iid Secretory Phospholipase A2Giid Spla2Spla2-IidPla2iidPhosphatidylcholine 2-Acylhydrolase 2dSecretory-Type Pla - Stroma-Associated Homolog |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482801Reactome: R-HSA-1482839Reactome: R-HSA-1482922Reactome: R-HSA-1482925Reactome: R-HSA-1483166 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Group Iid Secretory Phospholipase A2 antibodyAnti-Giid Spla2 antibodyAnti-Spla2-Iid antibodyAnti-Pla2iid antibodyAnti-Phosphatidylcholine 2-Acylhydrolase 2d antibodyAnti-Secretory-Type Pla - Stroma-Associated Homolog antibodyAnti-PLA2G2D antibodyAnti-SPLASH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
