| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospholipase A2 group XV (233-283 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLA2G15 |
| Gene ID: |
23659 |
| Uniprot ID: |
PAG15_HUMAN |
| Immunogen Region: |
233-283 aa |
| Specificity: |
This antibody detects endogenous levels of human PAG15 |
| Immunogen: |
Synthesized peptide derived from the human PAG15 at the amino acid range 233-283 |
| Post Translational Modifications | N-glycosylated. N-glycosylation is important for maturation of the enzyme and normal subcellular location. |
| Function | Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments. Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines. Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide. Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress. Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance. At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines. |
| Protein Name | Phospholipase A2 Group Xv1-O-Acylceramide SynthaseAcsLcat-Like LysophospholipaseLlplLysophospholipase 3Lysosomal Phospholipase A And AcyltransferaseLysosomal Phospholipase A2Lpla2 |
| Database Links | Reactome: R-HSA-1483115 |
| Cellular Localisation | LysosomeSecretedMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Phospholipase A2 Group Xv antibodyAnti-1-O-Acylceramide Synthase antibodyAnti-Acs antibodyAnti-Lcat-Like Lysophospholipase antibodyAnti-Llpl antibodyAnti-Lysophospholipase 3 antibodyAnti-Lysosomal Phospholipase A And Acyltransferase antibodyAnti-Lysosomal Phospholipase A2 antibodyAnti-Lpla2 antibodyAnti-PLA2G15 antibodyAnti-LYPLA3 antibodyAnti-UNQ341 antibodyAnti-PRO540 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
