| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PKMYT1 (75-362) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PKMYT1 |
| Gene ID: |
9088 |
| Uniprot ID: |
PMYT1_HUMAN |
| Immunogen Region: |
75-362 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 75-362 of human PKMYT1 (NP_004194.3). |
| Immunogen Sequence: |
HQLQPRRVSFRGEASETLQS PGYDPSRPESFFQQSFQRLS RLGHGSYGEVFKVRSKEDGR LYAVKRSMSPFRGPKDRARK LAEVGSHEKVGQHPCCVRLE QAWEEGGILYLQTELCGPSL QQHCEAWGASLPEAQVWGYL RDTLLALAHLHSQGLVHLDV KPANIFLGPRGRCKLGDFGL LVELGTAGAGEVQEGDPRYM APELLQGSYGTAADVFSLGL TILEVACNMELPHGGEGWQ |
| Post Translational Modifications | Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity. |
| Function | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. |
| Protein Name | Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory KinaseMyt1 Kinase |
| Database Links | Reactome: R-HSA-156711Reactome: R-HSA-69273Reactome: R-HSA-69478 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory Kinase antibodyAnti-Myt1 Kinase antibodyAnti-PKMYT1 antibodyAnti-MYT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
