| Post Translational Modifications | Palmitoylation is important for expression at the cell membrane and for channel activity. |
| Function | Homotetrameric, non-selective cation channel that is permeable to sodium, potassium, magnesium and calcium. Also forms functionnal heteromeric channels with PKD1, PKD1L1 and PKD1L3. Pore-forming subunit of a heterotetrameric, non-selective cation channel, formed by PKD1L2 and PKD1L3, that is permeable to sodium, potassium, magnesium and calcium and which may act as a sour taste receptor in gustatory cells.however, its contribution to sour taste perception is unclear in vivo and may be indirect. The homomeric and heteromeric channels formed by PKD1L2 and PKD1L3 are activated by low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus. Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription. The PKD1L1:PKD2L1 complex channel is mechanosensitive only at high pressures and is highly temperature sensitive. Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1 that produces a transient increase in intracellular calcium concentration upon hypo-osmotic stimulation (200 mOsm). May play a role in the perception of carbonation taste. May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH. |
| Protein Name | Polycystin-2-Like Protein 1Polycystin-2l1Polycystic Kidney Disease 2-Like 1 ProteinPolycystin-2 HomologPolycystin-LPolycystin-L1 |
| Database Links | |
| Cellular Localisation | Cell ProjectionCilium MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic VesicleInteraction With Pkd1l3 Is Required For Localization To The Cell MembraneInteraction With Pkd1 Is Required For Localization To The Cell Membrane |
| Alternative Antibody Names | Anti-Polycystin-2-Like Protein 1 antibodyAnti-Polycystin-2l1 antibodyAnti-Polycystic Kidney Disease 2-Like 1 Protein antibodyAnti-Polycystin-2 Homolog antibodyAnti-Polycystin-L antibodyAnti-Polycystin-L1 antibodyAnti-PKD2L1 antibodyAnti-PKD2L antibodyAnti-PKDL antibodyAnti-TRPP3 antibody |
Information sourced from Uniprot.org
