| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Polycystin-2-like protein 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PKD2L1 |
| Gene ID: |
9033 |
| Uniprot ID: |
PK2L1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PKD2L1 at Human |
| Immunogen: |
Synthesized peptide derived from human PKD2L1 |
| Post Translational Modifications | Palmitoylation is important for expression at the cell membrane and for channel activity. |
| Function | Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration. The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription. Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells. The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again. May play a role in the perception of carbonation taste. May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH. |
| Protein Name | Polycystin-2-Like Protein 1Polycystin-2l1Polycystic Kidney Disease 2-Like 1 ProteinPolycystin-2 HomologPolycystin-LPolycystin-L1 |
| Cellular Localisation | Cell ProjectionCilium MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic VesicleInteraction With Pkd1 Or Pkd1l3 Is Required For Localization To The Cell Membrane |
| Alternative Antibody Names | Anti-Polycystin-2-Like Protein 1 antibodyAnti-Polycystin-2l1 antibodyAnti-Polycystic Kidney Disease 2-Like 1 Protein antibodyAnti-Polycystin-2 Homolog antibodyAnti-Polycystin-L antibodyAnti-Polycystin-L1 antibodyAnti-PKD2L1 antibodyAnti-PKD2L antibodyAnti-PKDL antibodyAnti-TRPP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
