| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PKD2L1 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
PKD2L1 |
| Gene ID: |
9033 |
| Uniprot ID: |
PK2L1_HUMAN |
| Specificity: |
Specific for PKD2L1. |
| Immunogen: |
A synthetic peptide from human PKD2L1 conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | Palmitoylation is important for expression at the cell membrane and for channel activity. |
| Function | Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration. The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription. Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells. The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again. May play a role in the perception of carbonation taste. May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH. |
| Protein Name | Polycystin-2-Like Protein 1Polycystin-2l1Polycystic Kidney Disease 2-Like 1 ProteinPolycystin-2 HomologPolycystin-LPolycystin-L1 |
| Cellular Localisation | Cell ProjectionCilium MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic VesicleInteraction With Pkd1 Or Pkd1l3 Is Required For Localization To The Cell Membrane |
| Alternative Antibody Names | Anti-Polycystin-2-Like Protein 1 antibodyAnti-Polycystin-2l1 antibodyAnti-Polycystic Kidney Disease 2-Like 1 Protein antibodyAnti-Polycystin-2 Homolog antibodyAnti-Polycystin-L antibodyAnti-Polycystin-L1 antibodyAnti-PKD2L1 antibodyAnti-PKD2L antibodyAnti-PKDL antibodyAnti-TRPP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
