| Function | Component of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription. The PKD1L1:PKD2L1 channel complex is mechanosensitive only at high pressures and is highly temperature sensitive. Also involved in left/right axis specification downstream of nodal flow by forming a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. May function as a G-protein-coupled receptor. |
| Protein Name | Polycystin-1-Like Protein 1Polycystin-1l1Pc1-Like 1 ProteinPolycystic Kidney Disease Protein 1-Like 1 |
| Database Links | |
| Cellular Localisation | Cell ProjectionCilium MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Polycystin-1-Like Protein 1 antibodyAnti-Polycystin-1l1 antibodyAnti-Pc1-Like 1 Protein antibodyAnti-Polycystic Kidney Disease Protein 1-Like 1 antibodyAnti-PKD1L1 antibodyAnti-PC1L1 antibodyAnti-UNQ5785 antibodyAnti-PRO19563 antibody |
Information sourced from Uniprot.org
