Western blot analysis of lysates from Rat kidney, using PJVK Rabbit pAb (STJ11106888) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 40s.

Anti-PJVK antibody (STJ11106888)

⇓ Datasheet ⇓ SDS
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
STJ11106888
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General Information

Short DescriptionRabbit polyclonal PJVK antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents.
ApplicationsWB/ELISA
HostRabbit
ReactivityHuman/Rat
NoteSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

ClonalityPolyclonal
IsotypeIgG
ConjugationUnconjugated
ConcentrationLot specific
PurificationAffinity purification
Dilution RangeWB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
FormulationPBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3.
Storage InstructionStore at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Target Information

Gene SymbolPJVK
Gene ID494513
Uniprot IDPJVK_HUMAN
Immunogen SequenceKPLSMTDISLKEGTHIRVNL LNHNIPKGPCILCGMGNFKR ETVYGCFQCSVDGQKYVRLH AVPCFDIWHKRMK
SpecificityRecombinant protein of human PJVK.

Additional Info

Function Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation.
Protein Name Pejvakin
Autosomal Recessive Deafness Type 59 Protein
Database Links Reactome: R-HSA-9662360
Reactome: R-HSA-9662361
Cellular Localisation Peroxisome Membrane
Cell Projection
Cilium
Associates With The Peroxisomal Membrane
It Is Unclear Whether It Is Embedded Or Just Associated With The Peroxisomal Membrane
Localizes To Ciliary Rootlet
Alternative Antibody Names Anti-Pejvakin antibody
Anti-Autosomal Recessive Deafness Type 59 Protein antibody
Anti-PJVK antibody
Anti-DFNB59 antibody

Information sourced from Uniprot.org

Citations

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