| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | PJA1 |
| Gene ID: | 64219 |
| Uniprot ID: | PJA1_HUMAN |
| Immunogen Region: | 1-240 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PJA1 (NP_660095.1). |
| Immunogen Sequence: | MGQESSKPVWPNPTGGYQSN TGRRYGRRHAYVSFRPPTSQ RERIASQRKTNSEVPMHRSA PSQTTKRSRSPFSTTRRSWD DSESSGTNLNIDNEDYSRYP PREYRASGSRRGMAYGHIDS YGADDSEEEGAGPVERPPVR GKTGKFKDDKLYDPEKGARS LAGPPPHFSSFSRDVREERD KLDPVPAARCSASRADFLPQ SSVASQSSSEGKLATKGDSS ERERREQNLPARPSRAPVS |
| Tissue Specificity | Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex. |
| Post Translational Modifications | Substrate for E2-dependent ubiquitination. |
| Function | Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting. |
| Protein Name | E3 Ubiquitin-Protein Ligase Praja-1Praja1Ring Finger Protein 70Ring-Type E3 Ubiquitin Transferase Praja-1 |
| Database Links | Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Praja-1 antibodyAnti-Praja1 antibodyAnti-Ring Finger Protein 70 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Praja-1 antibodyAnti-PJA1 antibodyAnti-RNF70 antibody |
Information sourced from Uniprot.org