Anti-PIST/FIG/GOPC antibody (C-Term) (STJ70493)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PIST/FIG/GOPC (C-Term) is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Applications | Pep-ELISA/WB/IF |
| Host | Goat |
| Reactivity | Human/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx. 55kDa band observed in Human Brain (Frontal Cortex) lysates (calculated MW of 50.5kDa according to NP_065132.1). Recommended concentration: 0.05-0.2µg/ml.IF: This product |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | GOPC |
| Gene ID | 57120 |
| Uniprot ID | GOPC_HUMAN |
| Accession Number | NP_065132.1; NP_001017408.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | LDDLHTLYHKKSY |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_065132.1; NP_001017408.1). |
Additional Info
| Function | Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR. Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes. |
| Protein Name | Golgi-Associated Pdz And Coiled-Coil Motif-Containing ProteinCftr-Associated LigandFused In GlioblastomaPdz Protein Interacting Specifically With Tc10Pist |
| Database Links | Reactome: R-HSA-5627083Reactome: R-HSA-9013406 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneSynapsePostsynaptic DensityCell ProjectionDendriteEnriched In Synaptosomal And Postsynaptic Densities (Psd) FractionsExpressed In Cell Bodies And Dendrites Of Purkinje CellsLocalized At The Trans-Golgi Network (Tgn) Of Spermatids And The Medulla Of Round Spermatides |
| Alternative Antibody Names | Anti-Golgi-Associated Pdz And Coiled-Coil Motif-Containing Protein antibodyAnti-Cftr-Associated Ligand antibodyAnti-Fused In Glioblastoma antibodyAnti-Pdz Protein Interacting Specifically With Tc10 antibodyAnti-Pist antibodyAnti-GOPC antibodyAnti-CAL antibodyAnti-FIG antibody |
Information sourced from Uniprot.org