| Function | Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules. Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1. May play a role in the regulation of cellular cholesterol metabolism. |
| Protein Name | Type 1 Phosphatidylinositol 4 -5-Bisphosphate 4-PhosphataseType 1 Ptdins-4 -5-P2 4-PtasePtdins-4 -5-P2 4-Ptase ITransmembrane Protein 55b |
| Database Links | Reactome: R-HSA-6811555Reactome: R-HSA-8847453 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinLysosome MembraneCytoplasmic VesiclePhagosome MembraneCell Membrane |
| Alternative Antibody Names | Anti-Type 1 Phosphatidylinositol 4 -5-Bisphosphate 4-Phosphatase antibodyAnti-Type 1 Ptdins-4 -5-P2 4-Ptase antibodyAnti-Ptdins-4 -5-P2 4-Ptase I antibodyAnti-Transmembrane Protein 55b antibodyAnti-PIP4P1 antibodyAnti-C14orf9 antibodyAnti-TMEM55B antibody |
Information sourced from Uniprot.org
