| Tissue Specificity | Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. |
| Post Translational Modifications | Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. Phosphorylated on serine residues. |
| Function | Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3. |
| Protein Name | Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-BetaDiphosphoinositide Kinase 2-BetaPhosphatidylinositol 5-Phosphate 4-Kinase Type Ii BetaPi(5p 4-Kinase Type Ii BetaPip4kii-BetaPtdins(5p-4-Kinase Isoform 2-Beta |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-6811555Reactome: R-HSA-6811558Reactome: R-HSA-8847453 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinCell MembraneNucleusCytoplasmAssociated With The Plasma Membrane And The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta antibodyAnti-1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta antibodyAnti-Diphosphoinositide Kinase 2-Beta antibodyAnti-Phosphatidylinositol 5-Phosphate 4-Kinase Type Ii Beta antibodyAnti-Pi(5p 4-Kinase Type Ii Beta antibodyAnti-Pip4kii-Beta antibodyAnti-Ptdins(5p-4-Kinase Isoform 2-Beta antibodyAnti-PIP4K2B antibodyAnti-PIP5K2B antibody |
Information sourced from Uniprot.org
