| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PIP4K2B |
| Gene ID: | 8396 |
| Uniprot ID: | PI42B_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PIP4K2B (NP_003550.1). |
| Immunogen Sequence: | MSSNCTSTTAVAVAPLSASK TKTKKKHFVCQKVKLFRASE PILSVLMWGVNHTINELSNV PVPVMLMPDDFKAYSKIKVD NHLFNKENLPSRFKFKEYCP MVFRNLRERFGIDDQDYQNS VTRSAPINSDSQGRCGTRFL TTYDRRFVIKTVSSEDVAEM HNILKKYHQFIVECHGNTLL PQFLGMYRLTVDGVETYMVV TRNVFSHRLTVHRKYDLKGS TVAREASDKEKAKDLPTFK |
| Tissue Specificity | Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. |
| Post Translational Modifications | Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. Phosphorylated on serine residues. |
| Function | Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3. |
| Protein Name | Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta 1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta Diphosphoinositide Kinase 2-Beta Phosphatidylinositol 5-Phosphate 4-Kinase Type Ii Beta Pi(5p 4-Kinase Type Ii Beta Pip4kii-Beta Ptdins(5p-4-Kinase Isoform 2-Beta |
| Database Links | Reactome: R-HSA-1660499 Reactome: R-HSA-6811555 Reactome: R-HSA-6811558 Reactome: R-HSA-8847453 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Peripheral Membrane Protein Cell Membrane Nucleus Cytoplasm Associated With The Plasma Membrane And The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta antibody Anti-1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta antibody Anti-Diphosphoinositide Kinase 2-Beta antibody Anti-Phosphatidylinositol 5-Phosphate 4-Kinase Type Ii Beta antibody Anti-Pi(5p 4-Kinase Type Ii Beta antibody Anti-Pip4kii-Beta antibody Anti-Ptdins(5p-4-Kinase Isoform 2-Beta antibody Anti-PIP4K2B antibody Anti-PIP5K2B antibody |
Information sourced from Uniprot.org