Anti-PINX1 antibody (121-170 aa) (STJ95097)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PINX1 at the amino acid range 121-170
General Information
| Short Description | Rabbit polyclonal anti-PIN2/TERF1-interacting telomerase inhibitor 1 (121-170 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PINX1 |
| Gene ID | 54984 |
| Uniprot ID | PINX1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PINX1 at the amino acid range 121-170 |
| Immunogen Region | 121-170 aa |
| Specificity | PinX1 Polyclonal Antibody detects endogenous levels of PinX1 protein. |
Additional Info
| Post Translational Modifications | Cleaved by enterovirus protease 3C to promote apoptosis. |
| Function | Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. |
| Protein Name | Pin2/Terf1-Interacting Telomerase Inhibitor 1Liver-Related Putative Tumor SuppressorPin2-Interacting Protein X1Protein 67-11-3Trf1-Interacting Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusNucleolusChromosomeTelomereCentromereKinetochoreLocalizes In NucleoliAt Telomere Speckles And To The Outer Plate Of KinetochoresLocalization To The Kinetochore Is Mediated By Its Central Region And Depends On Ndc80 And Cenpe |
| Alternative Antibody Names | Anti-Pin2/Terf1-Interacting Telomerase Inhibitor 1 antibodyAnti-Liver-Related Putative Tumor Suppressor antibodyAnti-Pin2-Interacting Protein X1 antibodyAnti-Protein 67-11-3 antibodyAnti-Trf1-Interacting Protein 1 antibodyAnti-PINX1 antibodyAnti-LPTL antibodyAnti-LPTS antibody |
Information sourced from Uniprot.org