Anti-PIN4 antibody (STJA0009233)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PIN4
General Information
| Short Description | Rabbit polyclonal anti-Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PIN4 |
| Gene ID | 5303 |
| Uniprot ID | PIN4_HUMAN |
| Immunogen | Synthesized peptide derived from human PIN4 |
| Specificity | This antibody detects endogenous levels of PIN4 at Human, Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus. Isoform 2 is sumoylated with SUMO2 and SUMO3. |
| Function | Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Isoform 2 binds to double-stranded DNA. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 4Parvulin-14Par14Hpar14Parvulin-17Par17Hpar17Peptidyl-Prolyl Cis-Trans Isomerase Pin4Ppiase Pin4Peptidyl-Prolyl Cis/Trans Isomerase EpvhHepvhRotamase Pin4 |
| Database Links | |
| Cellular Localisation | Isoform 1: NucleusNucleolusCytoplasmCytoskeletonSpindleColocalizes In The Nucleolus During Interphase And On The Spindle Apparatus During Mitosis With Npm1Isoform 2: MitochondrionMitochondrion MatrixImported In A Time- And Membrane Potential-Dependent Manner To The Mitochondrial MatrixBut Without Concomitant Processing Of The ProteinDirected To Mitochondria By A Novel N-Terminal Domain That Functions As A Non-Cleavable Mitochondrial Targeting Peptide |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 4 antibodyAnti-Parvulin-14 antibodyAnti-Par14 antibodyAnti-Hpar14 antibodyAnti-Parvulin-17 antibodyAnti-Par17 antibodyAnti-Hpar17 antibodyAnti-Peptidyl-Prolyl Cis-Trans Isomerase Pin4 antibodyAnti-Ppiase Pin4 antibodyAnti-Peptidyl-Prolyl Cis/Trans Isomerase Epvh antibodyAnti-Hepvh antibodyAnti-Rotamase Pin4 antibodyAnti-PIN4 antibody |
Information sourced from Uniprot.org