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![Anti-PIGR nanobody [SAA1311] (STJN000084)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200697/412879/STJN000084-SDS-PAGE-1__59638.1749232422.jpg?c=1 "Anti-PIGR nanobody [SAA1311] (STJN000084)")
| Host: | Alpaca |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Alpaca monoclonal nanobody anti-Polymeric Immunoglobulin Receptor is suitable for use in ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SAA1311 |
| Conjugation: | Unconjugated |
| Isotype: | VHH-8His-Cys-tag |
| Formulation: | 0.01M PBS, pH 7.4. |
| Purification: | Purified by Nickel column. |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
| Gene Symbol: | PIGR |
| Gene ID: | 5284 |
| Uniprot ID: | PIGR_HUMAN |
| Function | Polymeric immunoglobulin receptor: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Secretory component: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells. |
| Protein Name | Polymeric Immunoglobulin ReceptorPigrPoly-Ig ReceptorHepatocellular Carcinoma-Associated Protein Tb6 Cleaved Into - Secretory Component |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Polymeric Immunoglobulin Receptor: Cell MembraneSingle-Pass Type I Membrane ProteinSecretory Component: Secreted |
| Alternative Nanobody Names | Anti-Polymeric Immunoglobulin Receptor nanobodyAnti-Pigr nanobodyAnti-Poly-Ig Receptor nanobodyAnti-Hepatocellular Carcinoma-Associated Protein Tb6 Cleaved Into - Secretory Component nanobodyAnti-PIGR nanobody |
Information sourced from Uniprot.org
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