| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PIBF1 (598-757) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIBF1 |
| Gene ID: |
10464 |
| Uniprot ID: |
PIBF1_HUMAN |
| Immunogen Region: |
598-757 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 598-757 of human PIBF1 (NP_006337.2). |
| Immunogen Sequence: |
LEHRKDQVTQLSQELDRANS LLNQTQQPYRYLIESVRQRD SKIDSLTESIAQLEKDVSNL NKEKSALLQTKNQMALDLEQ LLNHREELAAMKQILVKMHS KHSENSLLLTKTEPKHVTEN QKSKTLNVPKEHEDNIFTPK PTLFTKKEAPEWSKKQKMKT |
| Tissue Specificity | Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon. Expressed in the first trimester pregnancy decidua. Localized to extravillous cytotrophoblast (at protein level). Also found in syncytiotrophoblast and part of the villous cytotrophoblast. Isoform 1 is expressed in first trimester and term villous trophoblast.trophoblast cells can additionally express other isoforms. Overexpressed in solid tumors from stomach and uterus and in cells from ovary, cervical, breast, lymphoma and leukemia cancer. |
| Function | Plays a role in ciliogenesis. Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2. Isoform 4: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein. |
| Protein Name | Progesterone-Induced-Blocking Factor 1PibfCentrosomal Protein Of 90 KdaCep90 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSecretedIn Progesterone-Treated Astrocytoma Cells A 57 Kda Protein And Isoform 1 (90 Kda) Have Been DescribedBoth Being Located In The Intracellular Medium And SecretedRespective Predominant Forms Are Isoform 1 In The Intracellular And The 57 Kda Protein In The Extracellular MediumIsoform 1: NucleusCentriolar SatelliteLocalizes To Centriolar Satellites Throughout The Cell CycleIsoform 4: SecretedSecreted By Progesterone-Treated Lymphocytes |
| Alternative Antibody Names | Anti-Progesterone-Induced-Blocking Factor 1 antibodyAnti-Pibf antibodyAnti-Centrosomal Protein Of 90 Kda antibodyAnti-Cep90 antibodyAnti-PIBF1 antibodyAnti-C13orf24 antibodyAnti-PIBF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
