| Tissue Specificity | Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver. Expressed in the innear ear in the epithelium of the spinal organ of corti. |
| Function | Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. May play an important role in the inner ear development. (Microbial infection) Plays an essential role in Aichi virus RNA replication. Recruited by ACBD3 at the viral replication sites. (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. |
| Protein Name | Phosphatidylinositol 4-Kinase BetaPi4k-BetaPi4kbetaPtdins 4-Kinase BetaNpikPi4k92Pi4kiii |
| Database Links | Reactome: R-HSA-1660514 |
| Cellular Localisation | Endomembrane SystemMitochondrion Outer MembranePeripheral Membrane ProteinRough Endoplasmic Reticulum MembraneGolgi ApparatusGolgi Apparatus MembraneCytoplasmPerinuclear RegionFound In The Outer Membrane Of Mitochondria And Membranes Of The Rough Endoplasmic ReticulumRecruited To The Golgi Complex By The Small Gtpase Arf To Stimulate The Synthesis Of Phosphatidylinositol 45-Bisphosphate (Pip2) On The Golgi ComplexRecruited To The Golgi Apparatus Membrane By Acbd3Gga2 Is Also Involved In The Recruitment |
| Alternative Antibody Names | Anti-Phosphatidylinositol 4-Kinase Beta antibodyAnti-Pi4k-Beta antibodyAnti-Pi4kbeta antibodyAnti-Ptdins 4-Kinase Beta antibodyAnti-Npik antibodyAnti-Pi4k92 antibodyAnti-Pi4kiii antibodyAnti-PI4KB antibodyAnti-PIK4CB antibody |
Information sourced from Uniprot.org
