Anti-Phospho-TGFBR3-Thr842 antibody (801-850 aa) (STJ91321)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TGF beta Receptor III around the phosphorylation site of Thr842 at the amino acid range 801-850
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Transforming growth factor beta receptor type 3-Thr842 (801-850 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TGFBR3 |
| Gene ID | 7049 |
| Uniprot ID | TGBR3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TGF beta Receptor III around the phosphorylation site of Thr842 at the amino acid range 801-850 |
| Immunogen Region | 801-850 aa |
| Specificity | Phospho-TGF Beta RIII (T842) Polyclonal Antibody detects endogenous levels of TGF Beta RIII protein only when phosphorylated at T842. |
Additional Info
| Function | Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B. In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility. Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization. Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway. (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL. |
| Protein Name | Transforming Growth Factor Beta Receptor Type 3Tgf-Beta Receptor Type 3Tgfr-3BetaglycanTransforming Growth Factor Beta Receptor IiiTgf-Beta Receptor Type Iii |
| Database Links | Reactome: R-HSA-1502540Reactome: R-HSA-190370Reactome: R-HSA-190373Reactome: R-HSA-201451Reactome: R-HSA-2173789Reactome: R-HSA-9839383Reactome: R-HSA-9839389Reactome: R-HSA-9839394Reactome: R-HSA-9839397Reactome: R-HSA-9839406 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExtracellular SpaceExtracellular MatrixExists Both As A Membrane-Bound Form And As Soluble Form In Serum And In The Extracellular Matrix |
| Alternative Antibody Names | Anti-Transforming Growth Factor Beta Receptor Type 3 antibodyAnti-Tgf-Beta Receptor Type 3 antibodyAnti-Tgfr-3 antibodyAnti-Betaglycan antibodyAnti-Transforming Growth Factor Beta Receptor Iii antibodyAnti-Tgf-Beta Receptor Type Iii antibodyAnti-TGFBR3 antibody |
Information sourced from Uniprot.org