Anti-Phospho-STXBP1-Ser313 antibody (279-328 aa) (STJ90471)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human MUNC-18a around the phosphorylation site of Ser313 at the amino acid range 279-328
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Syntaxin-binding protein 1-Ser313 (279-328 aa) for use in WB and ELISA in Human, Mouse, Rat and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STXBP1 |
| Gene ID | 6812 |
| Uniprot ID | STXB1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human MUNC-18a around the phosphorylation site of Ser313 at the amino acid range 279-328 |
| Immunogen Region | 279-328 aa |
| Specificity | Phospho-Unc18-1 (S313) Polyclonal Antibody detects endogenous levels of Unc18-1 protein only when phosphorylated at S313. |
Additional Info
| Function | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes. May play a role in determining the specificity of intracellular fusion reactions. |
| Protein Name | Syntaxin-Binding Protein 1Munc18-1N-Sec1Protein Unc-18 Homolog 1Unc18-1Protein Unc-18 Homolog AUnc-18aP67 |
| Database Links | Reactome: R-HSA-181429 P61764-1Reactome: R-HSA-181430 P61764-1Reactome: R-HSA-210500 P61764-1Reactome: R-HSA-212676 P61764-1Reactome: R-HSA-264642 P61764-1Reactome: R-HSA-422356Reactome: R-HSA-6794361Reactome: R-HSA-888590 P61764-1 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Syntaxin-Binding Protein 1 antibodyAnti-Munc18-1 antibodyAnti-N-Sec1 antibodyAnti-Protein Unc-18 Homolog 1 antibodyAnti-Unc18-1 antibodyAnti-Protein Unc-18 Homolog A antibodyAnti-Unc-18a antibodyAnti-P67 antibodyAnti-STXBP1 antibodyAnti-UNC18A antibody |
Information sourced from Uniprot.org