• Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-Phospho-STMN2-Ser38 antibody (STJ194749)

SKU:
STJ194749

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Stathmin-2-Ser38 is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: STMN2
Gene ID: 11075
Uniprot ID: STMN2_HUMAN
Specificity: This antibody detects endogenous levels of Human Stathmin (phospho-Ser38)
Immunogen: Synthesized phosho peptide around human Stathmin (Ser38)
Post Translational Modifications Sumoylated. Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex. N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.
Function Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.
Protein Name Stathmin-2
Superior Cervical Ganglion-10 Protein
Protein Scg10
Database Links Reactome: R-HSA-9696273
Cellular Localisation Cytoplasm
Perinuclear Region
Cell Projection
Growth Cone
Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Axon
Golgi Apparatus
Endosome
Lamellipodium
Associated With Punctate Structures In The Perinuclear Cytoplasm
Axons
And Growth Cones Of Developing Neurons
Scg10 Exists In Both Soluble And Membrane-Bound Forms
Colocalized With Cib1 In Neurites Of Developing Hippocampal Primary Neurons
Colocalized With Cib1 In The Cell Body
Neuritis And Growth Cones Of Neurons
Colocalized With Cib1 To The Leading Edge Of Lamellipodia
Alternative Antibody Names Anti-Stathmin-2 antibody
Anti-Superior Cervical Ganglion-10 Protein antibody
Anti-Protein Scg10 antibody
Anti-STMN2 antibody
Anti-SCG10 antibody
Anti-SCGN10 antibody

Information sourced from Uniprot.org

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