• Western blot analysis of lysates from NIH/3T3 cells treated with EGF 200ng/ml 30', using STAM2 (Phospho-Tyr192) Antibody. The lane on the right is blocked with the phospho peptide.
  • Western blot analysis of 3T3 cells using Phospho-STAM2 (Y192) Polyclonal Antibody

Anti-Phospho-STAM2-Tyr192 antibody (161-210 aa) (STJ90559)

SKU:
STJ90559

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Signal transducing adapter molecule 2-Tyr192 (161-210 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: STAM2
Gene ID: 10254
Uniprot ID: STAM2_HUMAN
Immunogen Region: 161-210 aa
Specificity: Phospho-STAM2 (Y192) Polyclonal Antibody detects endogenous levels of STAM2 protein only when phosphorylated at Y192.
Immunogen: The antiserum was produced against synthesized peptide derived from the human STAM2 around the phosphorylation site of Tyr192 at the amino acid range 161-210
Post Translational Modifications Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Protein Name Signal Transducing Adapter Molecule 2
Stam-2
Hrs-Binding Protein
Database Links Reactome: R-HSA-182971
Reactome: R-HSA-5689880
Reactome: R-HSA-6807004
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Reactome: R-HSA-8875360
Reactome: R-HSA-9013420
Reactome: R-HSA-917729
Cellular Localisation Cytoplasm
Early Endosome Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Antibody Names Anti-Signal Transducing Adapter Molecule 2 antibody
Anti-Stam-2 antibody
Anti-Hrs-Binding Protein antibody
Anti-STAM2 antibody
Anti-HBP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance