| Host: | Rabbit |
| Applications: | WB/ICC |
| Reactivity: | Chicken/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Slingshot-1L-Ser-978 is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:1000 ICC 1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SSH1 |
| Gene ID: | 54434 |
| Uniprot ID: | SSH1_HUMAN |
| Specificity: | The antibody detects a 150 kDa* full length recombinant human SSH1L phosphoprotein and this reactivity is eliminated with lambda phosphatase treatment. The antibody also detects SSH1L on immunoblots of rat PC12 and mouse C2C12 cells that were stimula |
| Immunogen: | Slingshot-1L (Ser-978) antibody was generated from a phospho-peptide that included amino acids surrounding serine 978 in human SSH1L. This sequence has high homology to the conserved site in rat, mouse, chicken, and zebrafish SSH1L. The sequence also |
| Function | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. |
| Protein Name | Protein Phosphatase Slingshot Homolog 1 Ssh-Like Protein 1 Ssh-1l Hssh-1l |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Projection Lamellipodium Cleavage Furrow Midbody Also Recruited To Actin Rich Membrane Protrusions Such As Lamellipodia Which May Allow Local Control Of Actin Dynamics At Sites Of Cell Locomotion Also Localized To The Cleavage Furrow And The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Protein Phosphatase Slingshot Homolog 1 antibody Anti-Ssh-Like Protein 1 antibody Anti-Ssh-1l antibody Anti-Hssh-1l antibody Anti-SSH1 antibody Anti-KIAA1298 antibody Anti-SSH1L antibody |
Information sourced from Uniprot.org