Anti-Phospho-SOX2-Thr-118 antibody (STJA0005590)

SKU:
STJA0005590-100

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Host: Rabbit
Applications: WB/ICC
Reactivity: Chicken/Human/Mouse/Rat/Xenopus
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Sox2-Thr-118 is suitable for use in Western Blot and Immunocytochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
IHC
ICC 1:50
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Sox2
Gene ID: 20674
Uniprot ID: SOX2_MOUSE
Specificity: The antibody was cross adsorbed to unphosphorylated Sox2 (Thr-118) peptide before affinity purification using phospho-Sox2 (Thr-118) peptide. This antibody antibody detects a 34 kDa* protein on SDS-PAGE immunoblots of mouse F9 stem cells. This reacti
Immunogen: Phospho-Sox2 (Thr-118) synthetic peptide (coupled to carrier) corresponding to amino acids surrounding Thr-118 in mouse Sox2. This site is well conserved in rat and human Sox2, and has high homology with the conserved site in Sox1 (Thr-126) and Sox3
Post Translational Modifications Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. Methylation at Lys-44 and Lys-119 is necessary for the regulation of SOX2 proteasomal degradation. Ubiquitinated by WWP2, leading to proteasomal degradation.
Function Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.
Protein Name Transcription Factor Sox-2
Database Links Reactome: R-MMU-3769402
Cellular Localisation Nucleus
Cytoplasm
Nuclear Import Is Facilitated By Xpo4
A Protein That Usually Acts As A Nuclear Export Signal Receptor
Alternative Antibody Names Anti-Transcription Factor Sox-2 antibody
Anti-Sox2 antibody
Anti-Sox-2 antibody

Information sourced from Uniprot.org

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