| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Ras-related protein R-Ras-Tyr66 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RRAS |
| Gene ID: | 6237 |
| Uniprot ID: | RRAS_HUMAN |
| Specificity: | This antibody detects endogenous levels of R-Ras (Phospho-Tyr66) at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human R-Ras (Phospho-Tyr66) |
| Post Translational Modifications | S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability. |
| Function | Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity. |
| Protein Name | Ras-Related Protein R-RasP23 |
| Database Links | Reactome: R-HSA-399955Reactome: R-HSA-416550 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideInner Surface Of Plasma Membrane Possibly With Attachment Requiring Acylation Of The C-Terminal Cysteine (By Similarity With Ras) |
| Alternative Antibody Names | Anti-Ras-Related Protein R-Ras antibodyAnti-P23 antibodyAnti-RRAS antibody |
Information sourced from Uniprot.org