| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Phospho-Ras-related protein R-Ras-Tyr66 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RRAS |
| Gene ID: | 6237 |
| Uniprot ID: | RRAS_HUMAN |
| Specificity: | This antibody detects endogenous levels of R-Ras (Phospho-Tyr66) at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human R-Ras (Phospho-Tyr66) |
| Post Translational Modifications | S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability. |
| Function | GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes. Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity. |
| Protein Name | Ras-Related Protein R-RasP23 |
| Database Links | Reactome: R-HSA-399955Reactome: R-HSA-416550 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideInner Surface Of Plasma Membrane Possibly With Attachment Requiring Acylation Of The C-Terminal Cysteine (By Similarity With Ras) |
| Alternative Antibody Names | Anti-Ras-Related Protein R-Ras antibodyAnti-P23 antibodyAnti-RRAS antibody |
Information sourced from Uniprot.org
