Anti-Phospho-RPH3A-Ser234 antibody (STJA0003761)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser234 conjugated to KLH.
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Rabphilin 3A-Ser234 for use in WB and ICC in Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC |
| Host | Rabbit |
| Reactivity | Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000ICC 1:400 |
| Formulation | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Rph3a |
| Gene ID | 171039 |
| Uniprot ID | RP3A_RAT |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser234 conjugated to KLH. |
Additional Info
| Tissue Specificity | Specifically expressed in brain. |
| Post Translational Modifications | Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation. |
| Function | Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone. |
| Protein Name | Rabphilin-3aExophilin-1 |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell ProjectionDendritic SpinePostsynaptic Cell MembraneMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Rabphilin-3a antibodyAnti-Exophilin-1 antibodyAnti-Rph3a antibody |
Information sourced from Uniprot.org