Anti-Phospho-RBL1-Thr369 antibody (335-384 aa) (STJ91140)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RBL1 around the phosphorylation site of Thr369 at the amino acid range 335-384
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Retinoblastoma-like protein 1-Thr369 (335-384 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RBL1 |
| Gene ID | 5933 |
| Uniprot ID | RBL1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RBL1 around the phosphorylation site of Thr369 at the amino acid range 335-384 |
| Immunogen Region | 335-384 aa |
| Specificity | Phospho-p107 (T369) Polyclonal Antibody detects endogenous levels of p107 protein only when phosphorylated at T369. |
Additional Info
| Function | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor. |
| Protein Name | Retinoblastoma-Like Protein 1107 Kda Retinoblastoma-Associated ProteinP107Prb1 |
| Database Links | Reactome: R-HSA-1362277Reactome: R-HSA-1362300Reactome: R-HSA-1538133Reactome: R-HSA-2173796Reactome: R-HSA-6804114Reactome: R-HSA-69205Reactome: R-HSA-69231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Retinoblastoma-Like Protein 1 antibodyAnti-107 Kda Retinoblastoma-Associated Protein antibodyAnti-P107 antibodyAnti-Prb1 antibodyAnti-RBL1 antibody |
Information sourced from Uniprot.org