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Anti-Phospho-PTPN6-Y564 antibody (STJ117885)

Western blot analysis of extracts of HeLa and RAW 264. 7 cells, using Phospho-SHP1-Y564 antibody (STJ117885) at 1:2000 dilution. HeLa cell lysates were treated by CIP at 37°C for 1 hour. RAW 264. 7 cell lysates were treated by CIP at 37°C for 1 hour. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Enhanced Kit. Exposure time: 3min.
Western blot analysis of lysates from HeLa and RAW 264. 7 cells, using Phospho-SHP1-Y564 Rabbit polyclonal antibody (STJ117885) at 1:2000 dilution. HeLa cell lysates were treated by CIP at 37°C for 1 hour. RAW 264. 7 cell lysates were treated by CIP at 37°C for 1 hour. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% BSA. Detection: ECL Enhanced Kit. Exposure time: 3min.

Anti-Phospho-PTPN6-Y564 antibody (STJ117885)

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STJ117885

£129.50 - £639.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Phospho-PTPN6-Y564 is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	PTPN6
Gene ID:	5777
Uniprot ID:	PTN6_HUMAN
Immunogen:	A synthetic phosphorylated peptide around Y564 of human PTPN6 (NP_002822.2).
Immunogen Sequence:	DVYEN

Tissue Specificity	Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Post Translational Modifications	Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation. Phosphorylation at Tyr-564 enhances phosphatase activity.
Function	Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Protein Name	Tyrosine-Protein Phosphatase Non-Receptor Type 6 Hematopoietic Cell Protein-Tyrosine Phosphatase Protein-Tyrosine Phosphatase 1c Ptp-1c Protein-Tyrosine Phosphatase Shp-1 Sh-Ptp1
Database Links	Reactome: R-HSA-114604 Reactome: R-HSA-1433559 Reactome: R-HSA-201556 Reactome: R-HSA-210990 Reactome: R-HSA-388841 Reactome: R-HSA-389948 Reactome: R-HSA-391160 Reactome: R-HSA-432142 Reactome: R-HSA-512988 Reactome: R-HSA-5690714 Reactome: R-HSA-6798695 Reactome: R-HSA-877300 Reactome: R-HSA-877312 Reactome: R-HSA-9008059 Reactome: R-HSA-909733 Reactome: R-HSA-912526 Reactome: R-HSA-912694 Reactome: R-HSA-9705671 Reactome: R-HSA-982772 Reactome: R-HSA-983695
Cellular Localisation	Cytoplasm Nucleus In Neurons Translocates Into The Nucleus After Treatment With Angiotensin Ii Shuttles Between The Cytoplasm And Nucleus Via Its Association With Pdpk1
Alternative Antibody Names	Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 6 antibody Anti-Hematopoietic Cell Protein-Tyrosine Phosphatase antibody Anti-Protein-Tyrosine Phosphatase 1c antibody Anti-Ptp-1c antibody Anti-Protein-Tyrosine Phosphatase Shp-1 antibody Anti-Sh-Ptp1 antibody Anti-PTPN6 antibody Anti-HCP antibody Anti-PTP1C antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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