| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Phospho-Bifunctional polynucleotide phosphatase/kinase-Ser114/Thr118 for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PNKP |
| Gene ID: | 11284 |
| Uniprot ID: | PNKP_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human PNK1 (phospho-Ser114 or Thr118) |
| Immunogen: | Synthesized phosho peptide around human PNK1 (Ser114 and Thr118) |
| Function | Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. |
| Protein Name | Bifunctional Polynucleotide Phosphatase/KinaseDna 5'-Kinase/3'-PhosphatasePolynucleotide Kinase-3'-Phosphatase Includes - Polynucleotide 3'-Phosphatase2'(3'-Polynucleotidase - Polynucleotide 5'-Hydroxyl-Kinase |
| Database Links | Reactome: R-HSA-5649702 |
| Cellular Localisation | NucleusChromosomeLocalizes To Site Of Double-Strand Breaks |
| Alternative Antibody Names | Anti-Bifunctional Polynucleotide Phosphatase/Kinase antibodyAnti-Dna 5'-Kinase/3'-Phosphatase antibodyAnti-Polynucleotide Kinase-3'-Phosphatase Includes - Polynucleotide 3'-Phosphatase antibodyAnti-2'(3'-Polynucleotidase - Polynucleotide 5'-Hydroxyl-Kinase antibodyAnti-PNKP antibody |
Information sourced from Uniprot.org
