Host: |
Rabbit |
Applications: |
WB/IHC |
Reactivity: |
Human/Rat/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Phospho-Bifunctional polynucleotide phosphatase/kinase-Ser114/Thr118 is suitable for use in Western Blot and Immunohistochemistry research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
PNKP |
Gene ID: |
11284 |
Uniprot ID: |
PNKP_HUMAN |
Specificity: |
This antibody detects endogenous levels of Human PNK1 (phospho-Ser114 or Thr118) |
Immunogen: |
Synthesized phosho peptide around human PNK1 (Ser114 and Thr118) |
Function | Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. |
Protein Name | Bifunctional Polynucleotide Phosphatase/KinaseDna 5'-Kinase/3'-PhosphatasePolynucleotide Kinase-3'-Phosphatase Includes - Polynucleotide 3'-Phosphatase2'(3'-Polynucleotidase - Polynucleotide 5'-Hydroxyl-Kinase |
Database Links | Reactome: R-HSA-5649702 |
Cellular Localisation | NucleusChromosomeLocalizes To Site Of Double-Strand Breaks |
Alternative Antibody Names | Anti-Bifunctional Polynucleotide Phosphatase/Kinase antibodyAnti-Dna 5'-Kinase/3'-Phosphatase antibodyAnti-Polynucleotide Kinase-3'-Phosphatase Includes - Polynucleotide 3'-Phosphatase antibodyAnti-2'(3'-Polynucleotidase - Polynucleotide 5'-Hydroxyl-Kinase antibodyAnti-PNKP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance