Anti-Phospho-PLCG2-Tyr1217 antibody (1186-1235 aa) (STJ91048)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PLCG2 around the phosphorylation site of Tyr1217 at the amino acid range 1186-1235
General Information
| Short Description | Rabbit polyclonal anti-Phospho-1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-2-Tyr1217 (1186-1235 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related r |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLCG2 |
| Gene ID | 5336 |
| Uniprot ID | PLCG2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PLCG2 around the phosphorylation site of Tyr1217 at the amino acid range 1186-1235 |
| Immunogen Region | 1186-1235 aa |
| Specificity | Phospho-PLC Gamma 2 (Y1217) Polyclonal Antibody detects endogenous levels of PLC Gamma 2 protein only when phosphorylated at Y1217. |
Additional Info
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2Phosphoinositide Phospholipase C-Gamma-2Phospholipase C-IvPlc-IvPhospholipase C-Gamma-2Plc-Gamma-2 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-166016Reactome: R-HSA-1855204Reactome: R-HSA-202433Reactome: R-HSA-2029485Reactome: R-HSA-2424491Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-5607764Reactome: R-HSA-5621480Reactome: R-HSA-9027277Reactome: R-HSA-9664323Reactome: R-HSA-9679191Reactome: R-HSA-9680350Reactome: R-HSA-983695 |
| Cellular Localisation | Membrane Raft |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2 antibodyAnti-Phosphoinositide Phospholipase C-Gamma-2 antibodyAnti-Phospholipase C-Iv antibodyAnti-Plc-Iv antibodyAnti-Phospholipase C-Gamma-2 antibodyAnti-Plc-Gamma-2 antibodyAnti-PLCG2 antibody |
Information sourced from Uniprot.org