| Short Description : | Rabbit monoclonal Phospho-PLC gamma 2 (PLCG2)-Y1217-Y1217 antibody for use in WB, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM15154 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity purification |
| Dilution Range: | WB, 1:5000-1:30000IF/ICC, 1:100-1:400ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLCG2 |
| Gene ID: | 5336 |
| Uniprot ID: | PLCG2_HUMAN |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by CSF1R. Phosphorylated on tyrosine residues by BTK and SYK.upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity. |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2Phosphoinositide Phospholipase C-Gamma-2Phospholipase C-IvPlc-IvPhospholipase C-Gamma-2Plc-Gamma-2 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-166016Reactome: R-HSA-1855204Reactome: R-HSA-202433Reactome: R-HSA-2029485Reactome: R-HSA-2424491Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-5607764Reactome: R-HSA-5621480Reactome: R-HSA-9027277Reactome: R-HSA-9664323Reactome: R-HSA-9679191Reactome: R-HSA-9680350Reactome: R-HSA-983695 |
| Cellular Localisation | Membrane Raft |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2 antibodyAnti-Phosphoinositide Phospholipase C-Gamma-2 antibodyAnti-Phospholipase C-Iv antibodyAnti-Plc-Iv antibodyAnti-Phospholipase C-Gamma-2 antibodyAnti-Plc-Gamma-2 antibodyAnti-PLCG2 antibody |
Information sourced from Uniprot.org
