Anti-Phospho-PDE3A antibody (200-300) {Biotin} (STJ502604)

Name: Anti-Phospho-PDE3A antibody (200-300) {Biotin} (STJ502604)
SKU: STJ502604-100
Price: 761.07 USD
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationBiotin

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acid region 200-300 on mouse PDE3A protein. Phosphorylated Serine 290 & 292 residues.

STJ502604-100

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Short Description	Rabbit polyclonal antibody anti-Phospho-PDE3A (200-300) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Applications	ELISA/IP/WB
Host	Rabbit
Reactivity	Chicken/Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Biotin
Concentration	1.0-1.25 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	Pde3a
Gene ID	54611
Uniprot ID	PDE3A_MOUSE
Immunogen	Synthetic peptide taken within amino acid region 200-300 on mouse PDE3A protein. Phosphorylated Serine 290 & 292 residues.
Immunogen Region	200-300
Specificity	This antibody will detect PDE3A protein that has been phosphorylated at its putative PKB/Akt site.

Function	Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling.
Protein Name	Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a Cyclic Gmp-Inhibited Phosphodiesterase A Cgi-Pde A
Database Links	Reactome: R-MMU-418555
Cellular Localisation	Membrane Multi-Pass Membrane Protein Cytoplasm Cytosol
Alternative Antibody Names	Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a antibody Anti-Cyclic Gmp-Inhibited Phosphodiesterase A antibody Anti-Cgi-Pde A antibody Anti-Pde3a antibody

Information sourced from Uniprot.org