| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Lymphokine-activated killer T-cell-originated protein kinase-Thr9 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PBK |
| Gene ID: | 55872 |
| Uniprot ID: | TOPK_HUMAN |
| Immunogen Region: | 1-50 aa |
| Specificity: | Phospho-PBK (T9) Polyclonal Antibody detects endogenous levels of PBK protein only when phosphorylated at T9. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PBK/TOPK around the phosphorylation site of Thr9 at the amino acid range 1-50 |
| Post Translational Modifications | Phosphorylated.in a cell-cycle dependent manner at mitosis. |
| Function | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. |
| Protein Name | Lymphokine-Activated Killer T-Cell-Originated Protein KinaseCancer/Testis Antigen 84Ct84Mapkk-Like Protein KinaseNori-3Pdz-Binding KinaseSpermatogenesis-Related Protein KinaseSpkT-Lak Cell-Originated Protein Kinase |
| Alternative Antibody Names | Anti-Lymphokine-Activated Killer T-Cell-Originated Protein Kinase antibodyAnti-Cancer/Testis Antigen 84 antibodyAnti-Ct84 antibodyAnti-Mapkk-Like Protein Kinase antibodyAnti-Nori-3 antibodyAnti-Pdz-Binding Kinase antibodyAnti-Spermatogenesis-Related Protein Kinase antibodyAnti-Spk antibodyAnti-T-Lak Cell-Originated Protein Kinase antibodyAnti-PBK antibodyAnti-TOPK antibody |
Information sourced from Uniprot.org