• Western blot of mouse whole brain lysate showing specific labeling of the ~86 kDa PanK4 phosphorylated at Ser63 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is nearly eliminated with lambda phosphatase ( Lambda-Ptase, 1200 units for 30 minutes).

Anti-Phospho-PANK4-Thr63 antibody (STJA0003740)

SKU:
STJA0003740-100

£442.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse/Hamster/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-PanK4-Thr63 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Pank4
Gene ID: 269614
Uniprot ID: PANK4_MOUSE
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr63 conjugated to KLH.
Tissue Specificity Expressed in liver, kidney, brain cortex and eye lens (at protein level).
Function Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.
Protein Name 4'-Phosphopantetheine Phosphatase
Inactive Pantothenic Acid Kinase 4
Mpank4
Database Links Reactome: R-MMU-196783
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-4'-Phosphopantetheine Phosphatase antibody
Anti-Inactive Pantothenic Acid Kinase 4 antibody
Anti-Mpank4 antibody
Anti-Pank4 antibody

Information sourced from Uniprot.org

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