Anti-Phospho-Oct-1-Ser385 antibody (361-410 aa) (STJ91181)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human POU2F1/OCT1 around the phosphorylation site of Ser385 at the amino acid range 361-410
General Information
| Short Description | Rabbit polyclonal anti-Phospho-POU domain, class 2, transcription factor 1 and POU domain, class 2, transcription factor 2-Ser385 (361-410 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendati |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | POU2F2POU2F1 |
| Gene ID | 54525451 |
| Uniprot ID | PO2F2_HUMANPO2F1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human POU2F1/OCT1 around the phosphorylation site of Ser385 at the amino acid range 361-410 |
| Immunogen Region | 361-410 aa |
| Specificity | Phospho-Oct-1 (S385) Polyclonal Antibody detects endogenous levels of 41183 protein only when phosphorylated at S385. |
Additional Info
| Post Translational Modifications | Phosphorylated by PRKDC. |
| Function | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. |
| Protein Name | Pou Domain - Class 2 - Transcription Factor 1Nf-A1Octamer-Binding Protein 1Oct-1Octamer-Binding Transcription Factor 1Otf-1 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-6807505Reactome: R-HSA-749476Reactome: R-HSA-76071Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pou Domain - Class 2 - Transcription Factor 1 antibodyAnti-Nf-A1 antibodyAnti-Octamer-Binding Protein 1 antibodyAnti-Oct-1 antibodyAnti-Octamer-Binding Transcription Factor 1 antibodyAnti-Otf-1 antibodyAnti-POU2F1 antibodyAnti-OCT1 antibodyAnti-OTF1 antibody |
Information sourced from Uniprot.org