• Immunohistochemistry analysis of paraffin-embedded human brain, using MLK1/2 (Phospho-Thr312/266) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-MLK1/2-Thr312/266 antibody (281-330 aa) (STJ91210)

SKU:
STJ91210

$62.10 - $305.10
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Mitogen-activated protein kinase kinase kinase 9 and Mitogen-activated protein kinase kinase kinase 10-Thr312/266 (281-330 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MAP3K9
MAP3K10
Gene ID: 4293
4294
Uniprot ID: M3K9_HUMAN
M3K10_HUMAN
Immunogen Region: 281-330 aa
Specificity: Phospho-MLK1/2 (T312/266) Polyclonal Antibody detects endogenous levels of MLK1/2 protein only when phosphorylated at T312/266.
Immunogen: The antiserum was produced against synthesized peptide derived from the human MLK1/2 around the phosphorylation site of Thr312/266 at the amino acid range 281-330
Post Translational Modifications Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308.
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Protein Name Mitogen-Activated Protein Kinase Kinase Kinase 9
Mixed Lineage Kinase 1
Alternative Antibody Names Anti-Mitogen-Activated Protein Kinase Kinase Kinase 9 antibody
Anti-Mixed Lineage Kinase 1 antibody
Anti-MAP3K9 antibody
Anti-MLK1 antibody
Anti-PRKE1 antibody

Information sourced from Uniprot.org

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