• Western blot analysis of lysates from K562 cells treated with heat shock, using MKP-1/2 (Phospho-Ser296/318) Antibody. The lane on the right is blocked with the phospho peptide.
  • Western blot analysis of JK cells using Phospho-MKP-1/2 (S296/318) Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).
  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using MKP-1/2 (Phospho-Ser296/318) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of various cells using Phospho-MKP-1/2 (S296/318) Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-Phospho-MKP-1/2-Ser296/318 antibody (261-310 aa) (STJ90983)

SKU:
STJ90983

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Dual specificity protein phosphatase 1 and Dual specificity protein phosphatase 4-Ser296/318 (261-310 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applica
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DUSP1
DUSP4
Gene ID: 1843
1846
Uniprot ID: DUS1_HUMAN
DUS4_HUMAN
Immunogen Region: 261-310 aa
Specificity: Phospho-MKP-1/2 (S296/318) Polyclonal Antibody detects endogenous levels of MKP-1/2 protein only when phosphorylated at S296/318.
Immunogen: The antiserum was produced against synthesized peptide derived from the human MKP-1/2 around the phosphorylation site of Ser296/318 at the amino acid range 261-310
Post Translational Modifications Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.
Function Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Protein Name Dual Specificity Protein Phosphatase 1
Dual Specificity Protein Phosphatase Hvh1
Mitogen-Activated Protein Kinase Phosphatase 1
Map Kinase Phosphatase 1
Mkp-1
Protein-Tyrosine Phosphatase Cl100
Database Links Reactome: R-HSA-112409
Reactome: R-HSA-5675221
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Dual Specificity Protein Phosphatase 1 antibody
Anti-Dual Specificity Protein Phosphatase Hvh1 antibody
Anti-Mitogen-Activated Protein Kinase Phosphatase 1 antibody
Anti-Map Kinase Phosphatase 1 antibody
Anti-Mkp-1 antibody
Anti-Protein-Tyrosine Phosphatase Cl100 antibody
Anti-DUSP1 antibody
Anti-CL100 antibody
Anti-MKP1 antibody
Anti-PTPN10 antibody
Anti-VH1 antibody

Information sourced from Uniprot.org

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