Anti-Phospho-MAP3K1-Thr1402 antibody (1368-1417 aa) (STJ90946)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human MAP3K1 around the phosphorylation site of Thr1402 at the amino acid range 1368-1417
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Mitogen-activated protein kinase kinase kinase 1-Thr1402 (1368-1417 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP3K1 |
| Gene ID | 4214 |
| Uniprot ID | M3K1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human MAP3K1 around the phosphorylation site of Thr1402 at the amino acid range 1368-1417 |
| Immunogen Region | 1368-1417 aa |
| Specificity | Phospho-MEK Kinase-1 (T1402) Polyclonal Antibody detects endogenous levels of MEK Kinase-1 protein only when phosphorylated at T1402. |
Additional Info
| Function | Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 1Mapk/Erk Kinase Kinase 1Mek Kinase 1Mekk 1 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-2871796Reactome: R-HSA-933542Reactome: R-HSA-975138Reactome: R-HSA-975871 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 1 antibodyAnti-Mapk/Erk Kinase Kinase 1 antibodyAnti-Mek Kinase 1 antibodyAnti-Mekk 1 antibodyAnti-MAP3K1 antibodyAnti-MAPKKK1 antibodyAnti-MEKK antibodyAnti-MEKK1 antibody |
Information sourced from Uniprot.org