• Western blot with Anti-Phospho-KIRREL Antibody (STJ502567) with 1) NEPH1 peptide. Lane 2) STJ502567 with NEPH1 peptide. Lane 3) STJ502567 with PNEPH1 peptide. Antibody at 1:500 dilution in buffer.

Anti-Phospho-KIRREL-p737/738 antibody (STJ502567)

SKU:
STJ502567-100

£546.50
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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Chicken/Human/Mouse/Rat/Zebra Fish
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-KIRREL-p737/738 is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.45-0.65 µg/µl
Dilution Range: WB: 1:250
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:250
IHC: 1:250
ICC: 1:250
IF: 1:250
CFM: 1:250
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Kirrel1
Gene ID: 170643
Uniprot ID: KIRR1_MOUSE
Specificity: Intracelular domain.
Immunogen: Phosphorylated synthetic peptide with phospo tyrosine 737 and 738 on mouse Kin of IRRE-like protein 1.
Tissue Specificity Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Post Translational Modifications Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding. N-glycosylated.
Function Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Protein Name Kin Of Irre-Like Protein 1
Kin Of Irregular Chiasm-Like Protein 1
Nephrin-Like Protein 1
Database Links Reactome: R-MMU-373753
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Predominantly Located At Podocyte Slit Diaphragm
Alternative Antibody Names Anti-Kin Of Irre-Like Protein 1 antibody
Anti-Kin Of Irregular Chiasm-Like Protein 1 antibody
Anti-Nephrin-Like Protein 1 antibody
Anti-Kirrel1 antibody
Anti-Kirrel antibody
Anti-Neph1 antibody

Information sourced from Uniprot.org

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