• Immunohistochemistry analysis of paraffin-embedded human brain, using Interferon-gamma Receptor alpha (Phospho-Tyr457) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of lysates from COS7 cells, using Interferon-gamma Receptor alpha (Phospho-Tyr457) Antibody. The lane on the right is blocked with the phospho peptide.
  • Immunofluorescence analysis of A549 cells, using Interferon-gamma Receptor alpha (Phospho-Tyr457) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-IFNGR1-Tyr457 antibody (431-480 aa) (STJ91086)

SKU:
STJ91086

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Interferon gamma receptor 1-Tyr457 (431-480 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IFNGR1
Gene ID: 3459
Uniprot ID: INGR1_HUMAN
Immunogen Region: 431-480 aa
Specificity: Phospho-IFN-Gamma R Alpha (Y457) Polyclonal Antibody detects endogenous levels of IFN-Gamma R Alpha protein only when phosphorylated at Y457.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Interferon-gamma Receptor alpha around the phosphorylation site of Tyr457 at the amino acid range 431-480
Function Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1.
Protein Name Interferon Gamma Receptor 1
Ifn-Gamma Receptor 1
Ifn-Gamma-R1
Cdw119
Interferon Gamma Receptor Alpha-Chain
Ifn-Gamma-R-Alpha
Cd Antigen Cd119
Database Links Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-9679191
Reactome: R-HSA-9732724
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Interferon Gamma Receptor 1 antibody
Anti-Ifn-Gamma Receptor 1 antibody
Anti-Ifn-Gamma-R1 antibody
Anti-Cdw119 antibody
Anti-Interferon Gamma Receptor Alpha-Chain antibody
Anti-Ifn-Gamma-R-Alpha antibody
Anti-Cd Antigen Cd119 antibody
Anti-IFNGR1 antibody

Information sourced from Uniprot.org

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