| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Heterogeneous nuclear ribonucleoprotein K-Ser216 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HNRNPK |
| Gene ID: |
3190 |
| Uniprot ID: |
HNRPK_HUMAN |
| Specificity: |
Phospho-hnRNP K (S216) Polyclonal Antibody detects endogenous levels of hnRNP K protein only when phosphorylated at S216. |
| Immunogen: |
Synthesized phospho-peptide around the phosphorylation site of human hnRNP K (phospho Ser216) |
| Function | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation. |
| Protein Name | Heterogeneous Nuclear Ribonucleoprotein KHnrnp KTransformation Up-Regulated Nuclear ProteinTunp |
| Database Links | Reactome: R-HSA-4570464Reactome: R-HSA-72163Reactome: R-HSA-72203Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmCell ProjectionPodosomeRecruited To P53/Tp53-Responsive PromotersIn The Presence Of Functional P53/Tp53In Case Of Asfv InfectionThere Is A Shift In The Localization Which Becomes Predominantly Nuclear |
| Alternative Antibody Names | Anti-Heterogeneous Nuclear Ribonucleoprotein K antibodyAnti-Hnrnp K antibodyAnti-Transformation Up-Regulated Nuclear Protein antibodyAnti-Tunp antibodyAnti-HNRNPK antibodyAnti-HNRPK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
