| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-HDAC8-S39 is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:100-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HDAC8 |
| Gene ID: |
55869 |
| Uniprot ID: |
HDAC8_HUMAN |
| Immunogen: |
A phospho specific peptide corresponding to residues surrounding S39 of human HDAC8 |
| Immunogen Sequence: |
Email for sequence |
| Tissue Specificity | Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. |
| Post Translational Modifications | Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4. |
| Function | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones. |
| Protein Name | Histone Deacetylase 8Hd8Protein Deacetylase Hdac8Protein Decrotonylase Hdac8 |
| Database Links | Reactome: R-HSA-2122947Reactome: R-HSA-2467813 Q9BY41-1Reactome: R-HSA-2500257 Q9BY41-1Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054 |
| Cellular Localisation | NucleusChromosomeCytoplasmExcluded From The NucleoliFound In The Cytoplasm Of Cells Showing Smooth Muscle Differentiation |
| Alternative Antibody Names | Anti-Histone Deacetylase 8 antibodyAnti-Hd8 antibodyAnti-Protein Deacetylase Hdac8 antibodyAnti-Protein Decrotonylase Hdac8 antibodyAnti-HDAC8 antibodyAnti-HDACL1 antibodyAnti-CDA07 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
