| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Histone deacetylase 7-Ser155 (121-170 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HDAC7 |
| Gene ID: | 51564 |
| Uniprot ID: | HDAC7_HUMAN |
| Immunogen Region: | 121-170 aa |
| Specificity: | Phospho-HDAC7 (S155) Polyclonal Antibody detects endogenous levels of HDAC7 protein only when phosphorylated at S155. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human HDAC7A around the phosphorylation site of Ser155 at the amino acid range 121-170 |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. Also acetylates non-histone proteins, such as ALKBH5. |
| Protein Name | Histone Deacetylase 7 Hd7 Histone Deacetylase 7a Hd7a Protein Deacetylase Hdac7 |
| Database Links | Reactome: R-HSA-2122947 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-3108214 Reactome: R-HSA-350054 Reactome: R-HSA-8943724 |
| Cellular Localisation | Nucleus Cytoplasm In The Nucleus It Associates With Distinct Subnuclear Dot-Like Structures Shuttles Between The Nucleus And The Cytoplasm In Muscle Cells It Shuttles Into The Cytoplasm During Myocyte Differentiation The Export To Cytoplasm Depends On The Interaction With The 14-3-3 Protein Ywhae And Is Due To Its Phosphorylation |
| Alternative Antibody Names | Anti-Histone Deacetylase 7 antibody Anti-Hd7 antibody Anti-Histone Deacetylase 7a antibody Anti-Hd7a antibody Anti-Protein Deacetylase Hdac7 antibody Anti-HDAC7 antibody Anti-HDAC7A antibody |
Information sourced from Uniprot.org